There are no signs or symptoms that indicate bile duct cancer. It usually develops slowly and the symptoms are often very subtle. Jaundice (the skin turning yellow) and itching are the most common signs. Jaundice is caused by the accumulation in the skin of a component of bile (bilirubin) that normally empties into the intestines after traveling through the bile ducts.
Bloating, weight loss, decreased appetite, fever, nausea or an enlarging abdominal mass are all signs that may be attributable to bile duct cancer. Pain usually signifies advanced disease.